Section: New Results

Generalizing a mathematical model of prion aggregation allows strain coexistence and co-stability by including a novel misfolded species

Prions are proteins capable of adopting misfolded conformations and transmitting these conformations to other normally folded proteins. A distinct feature of prion propagation is the existence of different phenotypical variants, called strains. In order to conform to biological observations of strain coexistence and co-stability, we develop in [19] an extension of the classical model by introducing a novel prion species consistent with biological studies.